Publications

2022

  Samantha Sharma,¹Mateusz Opyrchal,^2,3and Xiongbin Lu^1,3.Harnessing tumorous flaws for immune supremacy: is miRNA-155 the weak link       in breast cancerprogression? JCI.2022.

2021

   Zhuolong Zhou,¹Kevin Van der Jeught,¹Yuanzhang Fang,¹Tao Yu,¹Yujing Li,¹Zheng Ao,²Sheng Liu,³Lu Zhang,^1,4Yang Yang,^1,5Haniyeh Eyvani,

  Mary L. Cox,⁶Xiyu Wang,¹Xiaoming He,⁷Guang Ji,⁴Bryan P. Schneider,^6,8Feng Guo,²Jun Wan,^1,3,6Xinna Zhang,^1,6,*andXiongbin Lu^1,3,6,

  An organoid-based screen for epigenetic inhibitors that stimulate antigen presentation and potentiate T-cell-mediated cytotoxicity. Nat Biomed    Eng.

 

Yujing Li*, Yifan Sun*, Michael Kulke, Torsten Hechler, Kevin Van der Jeught, Tianhan Dong, Bin He, Kathy D. Miller, Milan Radovich, Bryan P. Schneider, Andreas Pahl, XInna Zhang#, Xiongbin Lu#. Science Translational Medicine. 2021 (*co-first, #co-corresponding authors). 

 

2020

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Yu Tao, Dong Tianhan, Eyvani Haniyeh, Fang Yuanzhang, Wang Xiyu, Zhang Xinna*, Lu Xiongbin*. Metabolic interventions: A new insight into the cnacer immunotherapy. Archives of Biochemistry and Biophysics. 2020. (*co-corresponding author).

Sun L, Wan A, Zhou Z, Chen D, Liang H, Liu C, Yan S, Niu Y, Lin Z, Zhan S, Wang S, Bu X, He W, Lu X*, Xu A, Wan G. RNA-binding protein RALY reprograms mitochondrial metabolism via mediating miRNA processing in colorectal cancer. Gut. 2020. (*co-corresponding author).

Yuanzhang Fang, Lifei Wang, Changlin Wan, Yifan Sun, Kevin Van der Jeught, Zhuolong Zhou, Tianhan Dong, Kaman So, Tao Yu, Yujing Li, Haniyeh Eyvani, Austyn B Colter, Edward Dong, Sha Cao, Jin Wang, Bryan P Schneider, George E. Sandusky, Yunlong Liu, Chi Zhang, Xiongbin Lu, Xinna Zhang. Mal2 drives immune evasion by reducing antigen presentation on tumor cells. The Journal of Clinical Investigation. 2020 .

 

Jiangsheng Xu, James G Shamul, Hai Wang, John Lin, Pranay Agarwal, Mingrui Sun, Xiongbin Lu, Katherine HR Tkaczuk, Xiaoming He. Targeted Heating of Mitochondria Greatly Augments Nanoparticle‐Mediated Cancer Chemotherapy. Advanced Healthcare Materials. 2020

Hai Wang, Pranay Agarwal, Bin Jiang, Samantha Stewart, Xuanyou Liu, Yutong Liang, Baris Hancioglu, Amy Webb, John P Fisher, Zhenguo Liu, Xiongbin Lu, Katherine HR Tkaczuk, Xiaoming He. Bioinspired One Cell Culture Isolates Highly Tumorigenic and Metastatic Cancer Stem Cells Capable of Multilineage Differentiation. Advanced Science. 2020

 

Kevin Van der Jeught, Yifan Sun, Yuanzhang Fang, Zhuolong Zhou, Hua Jiang, Tao Yu, Jinfeng Yang, Malgorzata Maria Kamocka, Kaman So, George E. Sandusky, Michael Frieden, Harald Braun, Rudi Beyaert, Xiaoming He, Xinna Zhang, Chi Zhang, Sophie Paczesny, Xiongbin Lu. ST2 as checkpoint target for colorectal cancer immunotherapy. JCI Insight. 2020; Highlighted by JCI This Month, and in the Spotlight of ACIR.

 

2019

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Bin Chen, Yue Wu, Zheng Ao, Hogwei Cai, Asael Nunez, Yunhua Liu, John Foley, Kenneth Nephew, Xiongbin Lu, Feng Guo (2019) High-throughput acoustofluidic fabrication of tumor spheroids. Lab on a Chip

Wennan Chang, Changlin Wan, Xiaoyu Lu, Szu-wei Tu, Yu Zhang, Brooke Richardson, Yifan Sun, Yingnan Hou, Xinna Zhang, Yong Zang, Anru Zhang, Kun Huang, Milan Radovich, Yunlong Liu, Xiongbin Lu, Sha Cao, Chi Zhang (2019) A semi-supervised approach for cell phenotypic and functional estimation in tissue microenvironment Cold Spring Harbor Laboratory

Jiangsheng Xu, Yunhua Liu, Yujing Li, Hai Wang, Samantha Stewart, Kevin Van der Jeught, Pranay Agarwal, Yuntian Zhang, Sheng Liu, Gang Zhao, Jun Wan, Xiongbin Lu, Xiaoming He (2019) Precise targeting of POLR2A as a  therapeutic strategy for human triple negative breast cancer Nature Nanotechnology

  2018

 

Yunhua Liu, Jiangsheng Xu, Hyun Ho Choi, Cecil Han, Yuanzhang Fang, Yujing Li, Kevin Van der Jeught, Hanchen Xu, Lu Zhang, Michael Frieden, Lifei Wang, Haniyeh Eyvani, Yifan Sun, Gang Zhao, Yuntian Zhang, Sheng Liu, Jun Wan, Cheng Huang, Guang Ji, Xiongbin Lu, Xiaoming He, Xinna Zhang (2018). Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer. Nature Communications.

 

Yujing Li, Yunhua Liu, Hanchen Xu, Guanglong Jiang, Kevin Van der Jeught, Yuanzhang Fang, Zhuolong Zhou, Lu Zhang, Michael Frieden, Lifei Wang, Zhenhua Luo, Milan Radovich, Bryan P Schneider, Yibin Deng, Yunlong Liu, Kun Huang, Bin He, Jin Wang, Xiaoming He, Xinna Zhang, Guang Ji, Xiongbin Lu (2018). Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Nature Communications. 

 

Hai Wang, Pranay Agarwal, Yutong Liang, Jiangsheng Xu, Gang Zhao, Katherine HR Tkaczuk, Xiongbin Lu, Xiaoming He (2018). Enhanced cancer therapy with cold-controlled drug release and photothermal warming enabled by one nanoplatform. Biomaterials.

 

Kevin Van der Jeught, Han-Chen Xu, Yu-Jing Li, Xiong-Bin Lu, Guang Ji (2018). Drug resistance and new therapies in colorectal cancer. World Journal of Gastroenterology. 

 

Yi Niu, Arabella Wan, Ziyou Lin, Xiongbin Lu, Guohui Wan (2018). N6-Methyladenosine modification: a novel pharmacological target for anti-cancer drug development. Acta Pharmaceutica Sinica B

 

Cecil Han, Xiongbin Lu, Deepak Nagrath (2018). Regulation of protein metabolism in cancer. Molecular & Cellular Oncology.

 

Julia A Yaglom, Yongmei Wang, Amy Li, Zhenghu Li, Stephano Monti, Ilya Alexandrov, Xiongbin Lu, Michael Y Sherman (2018). Author Correction: Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations. Scientific Reports.

 

Hai Wang, Pranay Agarwal, Gang Zhao, Guang Ji, Christopher M Jewell, John P Fisher, Xiongbin Lu, Xiaoming He (2018). Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial. ACS Central Science.

 

Yunhua Liu, Hanchen Xu, Kevin Van der Jeught, Yujing Li, Sheng Liu, Lu Zhang, Yuanzhang Fang, Xinna Zhang, Milan Rodovich, Bryan P Schneider, Xiaoming He, Cheng Huang, Chi Zhang, Jun Wan, Guang Ji, Xiongbin Lu (2018). Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. The Journal of Clinical Investigation.

 

Julia A Yaglom, Yongmei Wang, Amy Li, Zhenghu Li, Stephano Monti, Ilya Alexandrov, Xiongbin Lu, Michael Y Sherman (2018). Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and finding synergistic drug combinations. Scientific Reports.

 

Hai Wang, Zan Gao, Xuanyou Liu, Pranay Agarwal, Shuting Zhao, Daniel W Conroy, Guang Ji, Jianhua Yu, Christopher P Jaroniec, Zhenguo Liu, Xiongbin Lu, Xiaodong Li, Xiaoming He (2018). Nature Communications.

 

Rajasekhara Reddy Katreddy, Lakshmi Reddy Bollu, Fei Su, Na Xian, Shivangi Srivastava, Rintu Thomas, Yubing Dai, Bing Wu, Yunlu Xu, Michael A Rea, James M Briggs, Qingyuan Zhang, Xiongbin Lu, Gangxiong Huang, Zhang Weihua (2018). Targeted reduction of the EGFR protein, but not inhibition of its kinase activity, induces mitophagy and death of cancer cells through activation of mTORC2 and Akt. Oncogenesis.

 

Wennan Chang, Changlin Wan, Yu Zhang, Kaman So, Brooke Richardson, Yifan Sun, Xinna Zhang, Kun Huang, Anru Zhang, Xiongbin Lu, Sha Cao, Chi Zhang (2018). ICTD: Inference of cell types and deconvolution--a next-generation deconvolution method for accurate assess cell population and activities in tumor microenvironment. bioRxiv.

 

2017

Yuanzhang Fang, Lu Zhang, Zhenghu Li, Yujing Li, Cheng Huang, Xiongbin Lu (2017). MicroRNAs in DNA damage response, carcinogenesis, and chemoresistance. International Review of Cell and Molecular Biology 333, 1-49.

 

Agarwal P, Wang H, Sun M, Xu J, Zhao S, Liu Z, Gooch KJ, Zhao Y, Lu X, He X (2017). Microfluidics Enabled Bottom-Up Engineering of 3D Vascularized Tumor for Drug Discovery. ACS Nano, (Epub ahead of print).

 

L Zhang, X Liu, X Lu, C Huang (2017). Prim-O-glucosylcimifugin induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells. Anti-Cancer Drugs 28 (9), 943-951

 

2016

Yang L, Achreja A, Yeung T, Mangala LS, Jiang D, Han C, Baddour J, Marini J, Ni J, Nakahara R, Wahlig S, Chiba L, Kim SH, Morse J, Pradeep S, Nagaraja AS, Haemmerle M, Kyunghee N, Derichsweiler M, Plackemeier T, Mercado-Uribe I, Lopez-Berestein G, Moss T,  Ram PT, Liu J, Lu X, Mok SC, Sood AK, Nagrath D (2016). Targeting Glutamine Synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth. Cell Metabolism,24(5):685-700.

 

Han C, Yang L, Choi HH, Baddour J, Achreja A, Liu Y, Li Y, Li J, Wan G, Huang C, Zhang X, Nagrath D, Lu X (2016). Amplification of USP13 drives ovarian tumor metabolism. Nature Communications, 7:13525.

Wang H, Agarwal P, Zhao S, Yu J, Lu X, He X (2016). A near infrared laser-activatable "nanobomb" for breaking the barriers to microRNA delivery. Advanced Materials, 28(2):347-55.

 

2015

Wang H, Agarwal P, Zhao S, Yu J, Lu X, He X (2015). A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of theranostic agents. Nature Communications, 6:10081.

 

Rao W, Wang H, Han J, Zhao S, Dumbleton J, Agarwal P, Zhang W, Zhao G, Yu J, Zynger DL, Lu X, He X (2015).Chitosan-Decorated Doxorubicin-Encapsulated Nanoparticle Targets and Eliminates Tumor Reinitiating Cancer Stem-like Cells. ACS Nano, 9(6):5725-40.

 

Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X (2015). TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature, 520(7549):697-701 (highlighted in Nature Reviews Cancer, Nature Reviews Clinical Oncology and Cancer Discovery).

 

2014

Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, Lu X (2014). The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Reports, 8(5):1447-60.

 

2013

Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, Zhang X, Lu X (2013). A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO Journal, 32(21):2833-47.

 

Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X (2013). DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Reports, 3(6):2100-12.

 

2011

Wan G, Mathur R, Hu X, Zhang X, Lu X (2011). microRNA response to DNA damage. Trends in Biochemical Sciences, 36(9):478-84.

 

Zhang X, Berger FG, Yang J, Lu X (2011). USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO Journal, 30(11):2177-89.

 

Zhang X, Wan G, Berger FG, He X, Lu X (2011). The ATM kinase induces microRNA biogenesis in the DNA damage response. Molecular Cell, 41:371-83 (commentary in the same issue and recommended by Faculty of 1000).

 

2010

Zhang W, Gilstrap K, Wu L, K C RB, Moss M, Wang Q, Lu X, He X (2010).  Synthesis and characterization of thermally responsive Pluronic-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano, 4(11):6747-59.

 

Zhang X, Wan G, Mlotshwa S, Vance V, Berger F, Chen H, Lu X (2010). Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA Damage Signaling pathway. Cancer Research, 70(18):7176-86. 

 

2009

Zhang X, Lin L, Guo H, Jones SN, Jochemsen A, Lu X (2009). Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Research, 69(20):7960-8.

 

2007

Lu X*, Ma O, Nguyen T, Jones SN. Oren M, Donehower LA (2007). The Wip1 phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell, 12(4):342-54 (profiled in Nature Reviews Cancer, * corresponding author).

 

2005

Lu X, Nannenga B., Donehower LA (2005). PPM1D dephosphorylates CHK1 and p53 and abrogates cell cycle checkpoints. Genes & Development, 19(10): 1162-74 (profiled in Nature Reviews Cancer and recommended by the Faculty of 1000).

 

2004

Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA (2004). The p53-Induced Oncogenic Phosphatase PPM1D Interacts with Uracil DNA Glycosylase and Suppresses Base Excision Repair. Molecular Cell, 15(4):  621-34.

 

2002

Lu X, Xiong Y, Silver J. (2002). Asymmetric requirement for cholesterol in receptor- bearing but not envelope-bearing membranes for fusion mediated by ecotropic murine leukemia virus. Journal of Virology, 76(13): 6701-9.

 

Tyner S, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Karsenty G, Bradley A, Donehower LA (2002), p53 mutant mice that display early ageing-associated phenotypes. Nature, 415(6867): 45-53.  (reported by Washington Post, New York Times, and BBC News). 

 

2000

2Lu X and Silver J (2000). Ecotropic murine leukemia virus receptor is physically associated with caveolin and membrane rafts. Virology, 276(2): 251-8 (featured as cover story).